MA-B2
Development of MA-B2,
an antibody therapeutic targeting BAG2
First Discovery of BAG2 Target Protein
- Plays a role in deactivating immune cell activity
- In various cancers, a large amount of BAG2 is secreted into the blood when cancer recurs or metastasizes
Development Roadmap of BAG2 Therapeutic and Diagnostic
- Antibody therapeutic
MA-B2 - Diagnostic Kit
MO-B2
- Cancer metastasis / relapse predictive biomarker
- Companion diagnostic development to propose optimal treatment method and confirm response rates
Mechanism of Action of Antibody Therapeutic (MA-B2)
During carcinogenesis, MA-B2 inhibits the metastatic activity of cathepsin B, an enzyme involved in cancer metastasis, and activates the immune system by blocking the immune activity inhibitory effect of BAG2 protein.